Table 1.
Studies included in review of pyrethroid effects to the placenta.
| Authors | Year | Country | Pesticide(s) | ||
|---|---|---|---|---|---|
| Epidemiological Studies | |||||
| Sample Size (N) | |||||
| Chevrier et al. | 2019 | South Africa | 751 | Metabolites (3-PBA, 4-F-3-PBA, cis-DCCA and trans-DCCA, cis-DBCA) | |
| Matsuki et al. | 2020 | Japan | 93,718 | Pyrethroids (unspecified) | |
| Schmidt et al. | 2016 | USA | 47 | Pyrethroids (unspecified) | |
| Zhang et al. | 2014 | Japan | 147 | Metabolites (3-PBA) | |
| in vitro Studies | |||||
| Model | Tissue | ||||
| Markus et al. | 2018 | Turkey | hpGSTP1–1 enzyme | Placenta | Deltamethrin |
| Mathiesen et al. | 2020 | Denmark | BeWo b30 cell line | Placenta | Cypermethrin |
| Zhao et al. | 2014 | China | JEG-3 cell line | Placenta | Bifenthrin |
| Animal Studies | |||||
| Model | Tissue(s) | ||||
| Elser et al. | 2020 | USA | CD1 mice | Amniotic fluid, placenta Fetal: brain, body Maternal: liver, serum |
α-Cypermethrin |
| Elser et al. | 2022 | USA | CD-1-IGS mice | Amniotic fluid, fetal body, placenta Maternal: serum, liver, ovaries, brain |
α-Cypermethrin and permethrin |
| Guo et al. | 2019 | China | ICR mice | Placenta | Fenvalerate |
| Irani et al. | 2022 | India | Holtzman strain rats | F1 offspring: testes, ovaries, spermatozoa | Cypermethrin |
| Lesseur et al. | 2023 | USA | C57BL/6 J mice | Fetal: brain, placenta | Deltamethrin |
| Murkunde et al. | 2012 | India | Crl: Wistar rats | Cord blood, Fetal: body, liver |
Cypermethrin |
| Vester et al. | 2020 | USA | C57BL/6NCrl wild-type mice | Fetal: midbrain | Deltamethrin |
| Wang et al. | 2017 | China | ICR mice | Placenta Fetal: serum Maternal: serum |
Fenvalerate |