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. 2023 Oct 20;12(1):2269634. doi: 10.1080/2162402X.2023.2269634

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — Increased IL-22 levels in human liver metastasis.

(a) Schematic overview of human liver metastasis. (b) IL22 and IL22RA1 mRNA levels in total liver were measured by qPCR. n ≥ 25 patients per group. (c) Flow cytometry of peri-metastatic and metastatic human liver. (d) Diagram showing the proportion of CD45+IL-22+ cells in peri-metastatic and metastatic human liver. (e) Cells were isolated from fresh peri-metastatic and metastatic liver tissue and analyzed by flow cytometry. (f) Diagram showing the proportion of CD4+IL-22+ cells in peri-metastatic and metastatic human liver. n = 7-10 patients per group. See also Figure S1. Data presented as mean ± SEM. ns > 0.05; ***:p ≤ 0.001 as assessed by the Mann-Whitney U test.