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. 2023 Oct 20;12(1):2269634. doi: 10.1080/2162402X.2023.2269634

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Th22 cells are the main source of IL-22 in established murine lung metastasis.

(a) Schematic overview of MC38 cell intravenous injection for forced lung metastasis induction. (b) Il22 mRNA levels in total lung with or without metastasis were measured by qPCR. n ≥ 6 mice per group. (c) Diagram showing the proportion of CD45+IL-22+ cells in healthy and metastatic mouse lungs. (d) Flow cytometry of isolated lymphocytes of healthy and metastatic mouse lung 21 days post-intravenous injection of MC38 cancer cells. (e) Cells were isolated from fresh healthy and metastatic lung tissue and analyzed by flow cytometry. See also Figure S2. (f) Diagram showing the proportion of CD4+IL-22+ cells in healthy and metastatic murine lung 21 days post MC38 cancer cell intravenous injection. Data presented as mean ± SEM. ns > 0.05; *:p < 0.05; **:p ≤ 0.01; ***:p ≤ 0.001 as assessed by Mann-Whitney U test.