Table 3.
Comparison of visual acuity outcomes at first, 6-month, and last visits
| Variable | Typically developinga | Neurodevelopmental disordersa | P valueb |
|---|---|---|---|
| First visit comparison | n = 406 | n = 54 | |
| Amblyopic eye VA, logMAR | 0.48 (0.4, 0.7) | 0.60 (0.4, 0.8) | 0.100 |
| Fellow eye VA, logMAR | 0.1 (0.0, 0.18) | 0.1 (0.0, 0.30) | 0.034c |
| IOD, logMAR | 0.4 (0.3, 0.6) | 0.4 (0.3, 0.6) | 0.604 |
| n = 350 | n = 38 | ||
| Log stereopsis | 5.99 (4.61, 9.21) | 8.01 (5.30, 9.21) | 0.101 |
| Analysis of improvement from first to 6-month visit | n = 276 | n = 35 | |
| Amblyopic eye VA, logMAR | 0.3 (0.18, 0.48) | 0.4 (0.3, 0.57) | 0.032c |
| Change in amblyopic eye VA, logMAR | −0.22 (−0.4, −0.12) | −0.18 (−0.37, −0.08) | 0.168 |
| Fellow eye VA, logMAR | 0.0 (0.0, 0.1) | 0.1 (0.0, 0.18) | 0.044c |
| Change in fellow eye VA, logMAR | 0.0 (−0.1, 0.0) | 0.0 (−0.09, 0.04) | 0.886 |
| IOD, logMAR | 0.2 (0.10, 0.38) | 0.22 (0.09, 0.41) | 0.678 |
| Change in IOD, logMAR | −0.20 (−0.33, −0.10) | −0.18 (−0.34, −0.05) | 0.200 |
| Percent with <0.20 (logMAR) of IOD | 130 (47.1%) | 14 (40.0%) | 0.539 |
| n = 241 | n = 27 | ||
| Log stereopsis | 4.61 (4.25, 8.01) | 5.99 (4.5, 9.21) | 0.123 |
| Change in log stereopsis | 0.0 (−1.2, 0.0) | 0.0 (0.0, 0.0) | 0.005c |
| Analysis of improvement at last visit | n = 406 | n = 54 | |
| Amblyopic eye VA, logMAR | 0.18 (0.1, 0.4) | 0.39 (0.18, 0.48) | 0.002c |
| Change in amblyopic eye VA, logMAR from first visit | −0.3 (−0.44,−0.12) | −0.23 (−0.4, −0.09) | 0.244 |
| Fellow eye VA, logMAR | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.18) | <0.001c |
| Change in fellow eye VA, logMAR | −0.08 (−0.12, 0.0) | 0.0 (−0.17, 0.0) | 0.510 |
| IOD, logMAR | 0.18 (0.08, 0.4) | 0.26 (0.1, 0.4) | 0.318 |
| Change in IOD (logMAR) from first visit | −0.2 (−0.38, −0.1) | −0.15 (−0.31, −0.02) | 0.087 |
| Percent with <0.20 (logMAR) of IOD | 211 (52.0%) | 23 (42.6%) | 0.250 |
| n = 367 | n = 42 | ||
| Log stereopsis | 4.61 (3.91, 8.01) | 5.30 (4.61, 8.91) | 0.028c |
| Change in log stereopsis from first visit | −0.32 (−1.38, 0.0) | 0.0 (−0.67, 0.0) | 0.042c |
| Treatment information | |||
| Treatment length, years | 2.27 (1.2, 4.36) | 2.56 (1.47, 4.75) | 0.160 |
| Number of visits | 6 (3, 9) | 6 (3, 10) | 0.868 |
| Average time requested between visits, years | 0.31 (0.25, 0.39) | 0.33 (0.25, 0.45) | 0.104 |
| Average follow-up time between visits, years | 0.5 (0.36, 0.82) | 0.65 (0.42, 0.97) | 0.023c |
IOD, interocular difference; LogMAR, logarithmic minimal angle of resolution; VA, visual acuity.
a
Data are presented as median (25th, 75th percentile) for continuous data and frequency (percentage) for categorical data.
b
Obtained using the Fisher exact test or Wilcoxon rank-sum test, as appropriate.
c
Denotes statistical significance.