Table 2 – List of fatty acid signaling drugs tested in diabetic models.

Contains a list of compounds targeting fatty acid signaling pathways discussed in the text, as a potential treatment for T1D. Columns (from left to right) indicate: 1) the compound name found in bibliography or common drug for the compound; 2) the abbreviated name of the specific target; 3) the mechanism of action reported for the specific target; 3) the diabetic experimental models where the compound has been tested in; 3) FDA approval information in humans to treat not-T1D pathologies (https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm); 4) references for the mentioned diabetic experimental models.

Compound name	Target	Type	Experimental models	FDA approved1	Reference
Fasiglifam	G protein-coupled receptor 40	Agonist	Human having T2D	No	[111,112]
FKGK18	Ca2+-Independent Phospholipase A2β	Inhibitor	NOD mice	No	[21]
GKT137831	NADPH Oxidase 1	Inhibitor	NOD mice & human with T1D	No	[36,137,138]
Grapiprant	receptor EP4	Agonist	NOD mice	No	[60]
GSK137647A	G protein-coupled receptor 120	Agonist	Diet-induced obesity mice model	No	[77]
GSK2256294	Soluble epoxide hydrolase	Inhibitor	Mice islets	No	[48]
ML127	12/15-lipoxygenase	Inhibitor	NOD mice, human islets & mice islets	No	[41,42]
ML171	NADPH Oxidase 1	Inhibitor	NOD mice	No	[36]
ML351	12/15-lipoxygenase	Inhibitor	NOD mice, human Islets & mice islets	No	[41,42]
ML355	12/15-lipoxygenase	Inhibitor	NOD mice, human islets, human Islets from T2D donors & mice islets	No	[41,42]
NS-398	Cyclooxygenase-2	Inhibitor	Rat Islet & human Islets	No	[59,133]
Rosiglitazone	G protein-coupled receptor 40	Agonist	Human with T1D	Yes	[114,115]
SC-236	Cyclooxygenase-2	Inhibitor	Rat pancreatic islet	No	[59]
SCO-267	G protein-coupled receptor 40	Agonist	N-STZ-1.5 Rats	No	[113]
Selexipag	Prostaglandin I2 receptor	Agonist	NOD mice	Yes	[64,65,140]
t-AUCB	Soluble epoxide hydrolase	Inhibitor	Mice islets	No	[46]
TPPU	Soluble epoxide hydrolase	Inhibitor	Mice islets	No	[47]
TUG-891	G protein-coupled receptor 120	Agonist	Diet-induced obesity mice model	No	[77]

¹Target-specific drugs approved by FDA for a variety of diseases. None of them is approved for T1D.