. Author manuscript; available in PMC: 2023 Oct 23.

Published in final edited form as: Clin Neurol Neurosurg. 2023 Sep 18;233:107984. doi: 10.1016/j.clineuro.2023.107984

Table 3.

RORB, no variant or variant versus AD, absent (no) or present (yes) in 502,494 subjects. The result is significant (p = 0.008, two-sided Fisher exact test). The total effect size of the variant on AD is small, 0.19%. But the decrease in effect size on AD, no variant to variant, is larger, 0.20–0.16%. Since the US prevalence of AD is 6,700,000 cases over age 65, the decrease in effect size represents 2680 cases of AD.

		Alzheimer’s Disease
		no	yes	total
RORB	no variant	353,882	710	354,592
RORB	percent	99.80%	0.20%	100.00%
RORB	variant	147,659	243	147,902
RORB	percent	99.80%	0.16%	100.00%
RORB	total	501,541	953	502,494
RORB	percent	99.80%	0.19%	100.00%