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. Author manuscript; available in PMC: 2024 Oct 5.
Published in final edited form as: Mol Cell. 2023 Sep 25;83(19):3421–3437.e11. doi: 10.1016/j.molcel.2023.08.029

Figure 5. RANK and TLR4-induced interaction of PGC1β with NCoR/HDAC3 prevents histone deacetylation by HDAC3.

Figure 5.

(A, B) Exogenous PGC1β was transiently expressed in PGC1β gRNA-introduced Cas9-Hoxb8 macrophages. Immunoprecipitants with anti-NCoR or HDAC3 antibody in the cells treated with or without RANKL (A) or KLA (B) for 6 hours in the presence or absence of RGFP966 were incubated with nucleosomal H3K27ac followed by immunoblotting with anti-H3K27ac or H3 antibody.