Figure 2.

Potency and selectivity of macrocyclic peptide inhibitors containing an alkyl backbone and their linear counterparts. (A) Structures of the macrocyclic peptide inhibitors and their linear counterparts. (B) Compound mean ± SEM EC₅₀ values against P. falciparum asexual blood stage W2 parasites of each inhibitor. Data were generated using 72 h dose–response assays (N, n = 2,2). (C) EC₅₀ values against W2 parasites and cellular selectivity indexes for P. falciparum parasites compared to primary mammalian HFF cells (listed as the ratio of HFF EC₅₀ to parasite EC₅₀ values).