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Effect of rifampin-loaded microspheres on viability of macrophages at the end of a 7-day dosinga
| Factor | Amt of rifampin (μg/ml) | Effect on MM6 (% viability after 7 days) | Amt of microspheres necessary to deliver equivalent concn of rifampin (μg/ml) | Effect on MM6 (% viability after 7 days) |
|---|---|---|---|---|
| MIC | 0.25 | 91 | 18 | 100 |
| 3× MIC | 0.75 | 77 | 54 | 100 |
| 8× MIC | 2.0 | 42 | 143 | 92 |
Microsphere formulation 5 (1.4 wt%) was used in these experiments.
