Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A: Binding pocket of HDAC6 in purple mesh generated by GetCleft showing the orientation of the difluoromethyl group determined in the crystal structure of the complex with 13 (PDB 8GD4). B: Substitution of the CHF2 group with a CF3 group yields a model of the complex with hydrolyzed 17 in the ring-opened form. The additional fluorine atom results in a clash with the backbone carbonyl of G582.
