Table 2. Comparison of Annual Decline with 95% confidence intervals in Estimated Glomerular Filtration Rate (eGFR) by Various Predictors.

Urine protein-creatinine ratio, urine albumin-creatinine ratio, and blood pressure were taken from the last measurements prior to the initiation of kidney replacement therapy. Acronyms: CKD, chronic kidney disease; NG, non-glomerular; G, glomerular; uPCR, urine protein-creatinine ratio; uACR, urine albumin-creatinine ratio; BP, blood pressure; pct, percentile (for age, gender, and height); and Tx, transplant.

Subgroup		No. of participants	Pre-Kidney Replacement Therapy			Post-Transplant
			No. of eGFR measurementsa	Annualized Decline in eGFR (%)b	P-value	No. of eGFR measurementsc	Annualized Decline in eGFR (%)d	P-value
CKD etiology	NG	182	1284	13.5 (11.6, 15.4)	<0.001	417	5.0 (2.9, 7.0)	0.94
	G	64	318	30.8 (27.7, 33.8)		175	5.1 (1.8, 8.3)
Race	Non-Black	205	1366	16.7 (14.7, 18.7)	0.005	518	5.1 (3.2, 6.9)	0.86
	Black	41	236	23.9 (19.4, 28.1)		74	4.6 (−0.2, 9.2)
uPCR (g/g)	≤2	121	872	13.2 (10.6, 15.7)	<0.001	289	3.7 (1.1, 6.2)	0.12
	>2	122	723	22.5 (20.0, 24.9)		299	6.5 (4.0, 8.8)
uACR (mg/g)	≤1250	116	807	14.0 (11.2, 16.6)	<0.001	275	2.8 (0.3, 5.3)	0.01
	>1250	127	788	21.3 (18.8, 23.7)		313	7.2 (4.8, 9.5)
Systolic BP (pct)	≤75	123	879	14.9 (12.2, 17.6)	0.001	281	2.5 (0.0, 5.0)	0.02
	>75	119	708	21.3 (18.6, 23.9)		307	6.5 (4.3, 8.6)
Diastolic BP (pct)	≤75	115	819	15.6 (12.7, 18.3)	0.02	285	3.1 (0.7, 5.4)	0.047
	>75	126	763	20.2 (17.5, 22.7)		300	6.4 (4.1, 8.6)
Preemptive Tx	Yes	132	927	14.7 (12.1, 17.2)	<0.001	260	4.1 (1.8, 6.4)	0.21
	No	114	675	22.1 (19.4, 24.8)		332	6.3 (3.7, 8.9)

^aMeasurements excluded for missing data: 7 for uPCR, 7 for uACR, 15 for SBP, and 20 for DBP.

^bIn terms of the equation in methods section: $100\times \left({1-\mathrm{e}}^{{\beta }_0}\right)$ for the first row and $100\times \left({1-\mathrm{e}}^{{\beta }_0+{\beta }_1}\right)$ for the second row of each factor and the p-value is for testing whether ${\beta }_1=0$.

^cMeasurements excluded for missing data: 4 for uPCR, 4 for uACR, 4 for SBP, and 7 for DBP.

^dIn terms of the equation in methods section: $100\times \left({1-\mathrm{e}}^{{\beta }_0+{\delta }_0}\right)$ for the first row and $100\times \left({1-\mathrm{e}}^{{\beta }_0+{\beta }_1+{\delta }_0+{\delta }_1}\right)$ for the second row of each factor and the p-value is for testing whether ${\beta }_1+{\delta }_1=0$.