Table I: Analysis of C-terminal tryptophan preferences among common HLA class I allotypes:
The table shows 90 HLA class I allotypes for which C-terminal tryptophan prevalence among 9–11-mer peptides was analyzed using previously published peptidome datasets (1,7). Tapasin dependencies derived from a previous study (15) are shown.
| HLA Class I allotype | Tapasin dependence (15) | PC tryptophan content (in percentage) (17) | HLA Class I allotype | Tapasin dependence (15) | PC tryptophan content (in percentage) (17) |
|---|---|---|---|---|---|
| A*01:01 | 32.11 | 0.26 | B*35:03 | 2.10 | 0.06 |
| A*02:01 | 2.02 | 0.00 | B*35:07 | ND | 0.86 |
| A*02:02 | 1.45 | 0.03 | B*37:01 | 3.13 | 0.00 |
| A*02:03 | ND | 0.00 | B*38:01 | 6.39 | 2.01 |
| A*02:04 | ND | 0.00 | B*38:02 | ND | 3.25 |
| A*02:05 | 1.49 | 0.03 | B*40:01 | 1.90 | 0.00 |
| A*02:06 | ND | 0.00 | B*40:02 | 1.71 | 0.08 |
| A*02:07 | ND | 0.03 | B*40:06 | ND | 0.00 |
| A*02:11 | ND | 0.09 | B*42:01 | 1.72 | 0.31 |
| A*03:01 | 3.14 | 0.06 | B*44:02 | 190.40 | 36.24 |
| A*11:01 | 4 | 0.02 | B*44:03 | 274.16 | 29.93 |
| A*11:02 | 3.99 | 0.00 | B*45:01 | 16.31 | 0.13 |
| A*23:01 | 2.36 | 4.40 | B*46:01 | 60.66 | 0.00 |
| A*24:02 | 3.61 | 6.69 | B*49:01 | 82.40 | 0.05 |
| A*24:07 | ND | 6.82 | B*50:01 | 286.17 | 0.45 |
| A*25:01 | 3.91 | 38.58 | B*51:01 | 4.92 | 0.18 |
| A*26:01 | 8.33 | 0.27 | B*52:01 | 17.51 | 0.17 |
| A*29:02 | 4.38 | 0.00 | B*53:01 | 1.96 | 34.05 |
| A*30:01 | 6.52 | 0.00 | B*54:01 | ND | 0.09 |
| A*30:02 | 4.54 | 0.00 | B*55:01 | 6.46 | 0.07 |
| A*31:01 | 3.67 | 0.00 | B*55:02 | ND | 0.07 |
| A*32:01 | 2.92 | 37.73 | B*56:01 | 4.60 | 0.00 |
| A*33:01 | 5.34 | 0.00 | B*57:01 | 28.43 | 59.30 |
| A*33:03 | 4.20 | 0.00 | B*57:03 | 2.46 | 23.69 |
| A*34:01 | ND | 0.04 | B*58:01 | 4.30 | 64.52 |
| A*34:02 | 4.66 | 0.06 | B*58:02 | 73.28 | 5.08 |
| A*36:01 | 16.33 | 0.11 | C*01:02 | 3.67 | 0.00 |
| A*66:01 | 3.77 | 0.00 | C*02:02 | 4.17 | 0.00 |
| A*68:01 | 1.17 | 0.17 | C*03:02 | 3.19 | 0.20 |
| A*68:02 | 1.19 | 0.00 | C*03:03 | 3.01 | 0.57 |
| A*74:01 | 2.31 | 0.04 | C*03:04 | 2.32 | 0.74 |
| B*07:02 | 2.37 | 0.31 | C*04:01 | 13.59 | 0.96 |
| B*07:04 | ND | 0.14 | C*04:03 | ND | 0.81 |
| B*08:01 | 23.78 | 0.17 | C*05:01 | 1.68 | 0.52 |
| B*13:01 | ND | 12.62 | C*06:02 | 7.43 | 0.06 |
| B*13:02 | 12.35 | 0.04 | C*07:01 | 1.38 | 0.48 |
| B*14:02 | 7.68 | 0.09 | C*07:02 | 1.63 | 0.19 |
| B*15:01 | 6.10 | 0.14 | C*07:04 | 1.69 | 0.00 |
| B*15:02 | ND | 0.42 | C*08:02 | 1.97 | 0.18 |
| B*15:03 | 7.52 | 0.11 | C*12:02 | 2.83 | 0.00 |
| B*15:10 | 3.72 | 0.13 | C*12:03 | 3.76 | 2.74 |
| B*15:17 | ND | 3.20 | C*14:02 | 3.19 | 0.53 |
| B*18:01 | 2.40 | 0.92 | C*15:02 | 3.31 | 0.12 |
| B*27:05 | 3.38 | 0.12 | C*16:01 | 5.98 | 1.72 |
| B*35:01 | 1.26 | 1.79 | C*17:01 | 2.92 | 0.12 |
ND, not determined