Table 3.
Contributions to variance in targeted RNA sequencing to measure the PI3Kges gene expression signature (left) and the SETER/PR gene expression signature (right) in a mixed-effects model including 10 effusion specimens, 4 time points, 3 preparation conditions, and 2 technical replicates. Abbreviations: LCI, lower confidence interval; UCI, upper confidence interval; CS_C, cytospin slides fixed in Carnoy’s solution; CS_E, cystopin slides fixed in 95% ethanol.
| PI3 kinase Signature (PI3Kges) | SETER/PR signature | |||||
|---|---|---|---|---|---|---|
| Variable | Coefficient | Standard Error | P-Value | Coefficient | Standard Error | P-Value |
| Intercept | −1.42 | 0.35 | 2.5E-03 | −0.76 | 0.43 | 1.1E-01 |
| Timepoint | −0.04 | 0.02 | 1.4E-01 | −0.081 | 0.01 | 9.3E-07 |
| Method (CS_C) | 0.05 | 0.08 | 5.4E-01 | 0.06 | 0.07 | 4.1E-01 |
| Method (CS_E) | 0.46 | 0.08 | 1.3E-07 | 0.48 | 0.07 | 5.0E-11 |
| Timepoint:Method (CS_C) | −0.01 | 0.02 | 6.8E-01 | 0.00 | 0.02 | 8.6E-01 |
| Timepoint:Method (CS_E) | −0.020 | 0.020 | 3.32E-01 | −0.03 | 0.02 | 5.80E-02 |