Table 3.
Associations of CT emphysema subtypes labelled on cardiac CT scans from 2000–02 with incident clinical events and incident airflow limitation in MESA.
| N Events Person-years |
Rate per 10,000 person-years | Combined Bronchitis-Apical Emphysema HR per 10% increment (95% CI) |
Diffuse Emphysema HR per 10% increment (95% CI) |
Senile Emphysema HR per 10% increment (95% CI) |
Restrictive CPFE HR per 10% increment (95% CI) |
Obstructive CPFE HR per 10% increment (95% CI) |
Vanishing Lung Emphysema HR per 10% increment (95% CI) |
|
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| CLRD hospitalization (N=6,658) | ||||||||
| Unadjusted | 148 | 3.2 (2.8, 3.7) | 1.6 (1.3, 1.9) | 1.4 (0.9, 2.0) | 1.7 (1.3, 2.2) | 1.6 (1.2, 2.2) | 10.7 (5.6, 20.8) | |
| Model 1 | 77,466 | 19.1 | 3.3 (2.8, 3.9) | 1.9 (1.6, 2.3) | 1.3 (0.9, 1.9) | 1.3 (0.9, 1.8) | 1.2 (0.9, 1.8) | 10.8 (5.3, 21.9) |
| Model 2 | 2.9 (2.3, 3.6) | 1.5 (1.1, 1.9) | 0.8 (0.5, 1.3) | 1.0 (0.6, 1.7) | 1.4 (0.8, 2.2) | 1.1 (0.4, 3.1) | ||
| CLRD mortality (N=6,658) | ||||||||
| Unadjusted | 74 | 3.1 (2.6, 3.6) | 1.9 (1.6, 2.4) | 1.9 (1.2, 3.1) | 1.8 (1.3, 2.6) | 1.9 (1.4, 2.7) | 13.0 (6.5, 26.2) | |
| Model 1 | 78,096 | 9.5 | 2.5 (2.1, 3.0) | 1.8 (1.5, 2.3) | 1.6 (0.9, 2.7) | 1.6 (1.0, 2.3) | 1.6 (1.1, 2.2) | 7.0 (3.2, 15.5) |
| Model 2 | 2.2 (1.7, 2.9) | 1.5 (1.1, 2.0) | 0.9 (0.5, 1.6) | 0.99 (0.5, 1.9) | 1.8 (1.0, 3.1) | 1.3 (0.4, 4.0) | ||
| All-cause mortality (N=6,658) | ||||||||
| Unadjusted | 1,131 | 1.7 (1.5, 1.9) | 1.1 (0.9, 1.2) | 1.0 (0.9, 1.2) | 1.2 (0.9, 1.4) | 1.0 (0.8, 1.3) | 4.3 (2.7, 7.1) | |
| Model 1 | 78,096 | 144.8 | 1.5 (1.3, 1.7) | 1.0 (0.9, 1.1) | 0.9 (0.8, 1.1) | 1.0 (0.9, 1.3) | 0.9 (0.8, 1.1) | 3.3 (2.0, 5.5) |
| Model 2 | 1.6 (1.3, 1.8) | 0.9 (0.8, 0.9) | 1.0 (0.8, 1.2) | 1.1 (0.8, 1.4) | 0.9 (0.7, 1.2) | 1.0 (0.5, 2.1) | ||
| Incident airflow limitation (N=2,324) | ||||||||
| Unadjusted | 364 | 6.9 (3.0, 15.8) | 1.5 (1.3, 1.8) | 1.7 (1.3, 2.1) | 1.3 (0.9, 1.9) | 1.2 (0.9, 1.6) | -- | |
| Model 1 | 31,931 | 114.0 | 7.1 (3.2, 15.7) | 1.5 (1.3, 1.8) | 1.6 (1.3, 2.0) | 1.2 (0.8, 1.7) | 1.4 (1.1, 1.8) | -- |
| Model 2 | 2.9 (1.01, 8.5) | 1.4 (1.1, 1.7) | 1.2 (0.9, 1.6) | 1.1 (0.7, 1.7) | 1.1 (0.8, 1.6) | -- | ||
Airflow limitation defined by prebronchodilator ratio of the forced expiratory volume in one second to the forced vital capacity <0.70. Airflow limitation model for the vanishing lung emphysema subtype did not converge. HR are per 10% increment in CT emphysema subtype.
Abbreviations: HR=hazard ratio, CPFE=combined pulmonary fibrosis/emphysema, CLRD=Chronic lower respiratory disease.
Model 1. Adjusted for age, sex, race/ethnicity, height, weight, smoking status, pack-years, and scanner manufacturer.
Model 2. Additionally adjusted for other CT emphysema subtypes