Table 2.
Clinical and Demographic Characteristics of Included Trials
| Variable | Trial Result | p-value+ | |
|---|---|---|---|
| Positive | Negative | ||
| (ES<0) | (ES>0) | ||
| N=45 | N=15 | ||
|
| |||
| Trial Duration (weeks) | 11.8 (9.9) | 14.8 (11.2) | 0.06 |
| Sample size (anti-inflammatory group) | 30 (18) | 52 (40) | 0.09 |
| Age (years) | 38.7 (9.5) | 37.8 (9.1) | 0.75 |
| Sex (% male) | 46.7 (31.0) | 65.6 (22.4) | 0.02 |
| Smoking (% yes) | 55.6 (18.2) | N/A | |
| BMI | 26.5 (4.0) | 28.4 (0.8) | 0.28 |
| Illness duration (years) | 14.9 (10.1) | 12.1 (9.8) | 0.54 |
| Age of Onset (years) | 24.6 (3.5) | 24.4 (4.1) | 0.88 |
| PANSS Total | 80.7 (17.5) | 76.1 (14.6) | 0.38 |
| PANSS Positive | 19.8 (5.6) | 19.9 (3.9) | 0.83 |
| PANSS Negative | 21.0 (5.2) | 22.1 (4.0) | 0.59 |
| PANSS General | 40.4 (9.9) | 42.6 (4.9) | 0.56 |
| Study Quality Score | 4.9 (1.4) | 3.9 (1.2) | 0.03 |
| n (%) | n (%) | ||
|
| |||
| Geography | 0.44 | ||
| Middle East | 15 (33.3) | 4 (26.7) | |
| Europe | 9 (20.0) | 2 (13.3) | |
| United States | 6 (13.3) | 5 (11.1) | |
| Australia | 9 (20.0) | 1 (6.7) | |
| Asia | 5 (11.1) | 2 (13.3) | |
| South Africa | 1 (2.2) | 1 (6.7) | |
Selected sociodemographic and clinical characteristics of included trials, stratified based on whether the overall effect size favored anti-inflammatory (ES<0) or placebo (ES>0).