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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Brain Behav Immun. 2023 Aug 20;114:154–162. doi: 10.1016/j.bbi.2023.08.001

Table 2.

Clinical and Demographic Characteristics of Included Trials

Variable Trial Result p-value+
Positive Negative
(ES<0) (ES>0)
N=45 N=15

Trial Duration (weeks) 11.8 (9.9) 14.8 (11.2) 0.06
Sample size (anti-inflammatory group) 30 (18) 52 (40) 0.09
Age (years) 38.7 (9.5) 37.8 (9.1) 0.75
Sex (% male) 46.7 (31.0) 65.6 (22.4) 0.02
Smoking (% yes) 55.6 (18.2) N/A
BMI 26.5 (4.0) 28.4 (0.8) 0.28
Illness duration (years) 14.9 (10.1) 12.1 (9.8) 0.54
Age of Onset (years) 24.6 (3.5) 24.4 (4.1) 0.88
PANSS Total 80.7 (17.5) 76.1 (14.6) 0.38
PANSS Positive 19.8 (5.6) 19.9 (3.9) 0.83
PANSS Negative 21.0 (5.2) 22.1 (4.0) 0.59
PANSS General 40.4 (9.9) 42.6 (4.9) 0.56
Study Quality Score 4.9 (1.4) 3.9 (1.2) 0.03
n (%) n (%)

Geography 0.44
 Middle East 15 (33.3) 4 (26.7)
 Europe 9 (20.0) 2 (13.3)
 United States 6 (13.3) 5 (11.1)
 Australia 9 (20.0) 1 (6.7)
 Asia 5 (11.1) 2 (13.3)
 South Africa 1 (2.2) 1 (6.7)

Selected sociodemographic and clinical characteristics of included trials, stratified based on whether the overall effect size favored anti-inflammatory (ES<0) or placebo (ES>0).