Table 1.
Subject characteristics and miR-142 levels, including by Type 1 diabetes complications status. Data showed: mean ± SD, median (LQ, UQ) or mean (95% CI).
| Non-diabetic | All T1D | T1D-No Cx |
T1D-Cx | Pb | |
|---|---|---|---|---|---|
|
| |||||
| N (M/F) | 33 (16/17) | 69 (34/35) | 35 (16/19) | 34 (18/16) | 0.77 |
| Age (yrs) | 43 ± 13 | 39 ± 13 | 37 ± 13 | 42 ± 13 | 0.10 |
| T1D duration (yrs) | – | 24 ± 13 | 20 ± 14 | 28 ± 11‡ | 0.01 |
| WHR (cm/cm) | 0.86 ± 0.10 | 0.87 ± 0.08 | 0.82 ± 0.06 | 0.91 ± 0.08‡ | 0.0005 |
| BMI (kg/m2) | 26.7 ± 4.8† | 27.8 ± 6.5 | 24.8 ± 2.7 | 31.0 ± 7.7‡ | 0.0001 |
| BP (mmHg) | 121†/69† ± 12/9 | 132/73 ±19/10 | 125/70 ± 11/7 | 140‡/75 ± 22/12 | <0.0001/0.04 |
| HbAlc (%) | 5.2 ± 0.4†,‡ | 8.1 ± 1.5 | 7.9 ± 1.2 | 8.3 ± 1.7 | <0.0001 |
| HbAlc (mmol/mol) | 33.3 ± 4.7†,‡ | 65.4 ± 16.4 | 63.2 ± 12.8 | 67.4 ± 19.1 | <0.0001 |
| 1,5AG (μg/mL) | 18.9 ± 9.2†,‡ | 4.8 ± 3.2 | 4.1 ± 2.0 | 4.1 ± 3.9 | 0.0005 |
| Total Cholesterol (TC) (mM) |
5.2 ± 1.1‡ | 4.7 ± 1.3 | 4.3 ± 0.8 | 5.1 ± 1.7‡ | 0.01 |
| Fasting triglycerides (TG) (mM) |
1 (0.7, 1.4) | 0.8 (0.6, 1.2) | 0.7 (0.6, 1.0) | 1.0 (0.8, 2.2)‡ | 0.01 |
| HDL-C (mM) | 1.5 ± 0.4 | 1.5 ± 0.4 | 1.5 ± 0.4 | 1.4 ± 0.5 | 0.81 |
| LDL-C (mM) | 3.2 ± 1.1‡ | 2.7 ± 1.1 | 2.4 ± 0.7 | 3.0 ± 1.4 | 0.02 |
| eGFR (ml/min/1.73 m2) | 111 (102, 120) | 100 (84, 120) | 104 (93, 124) | 96 (78, 116) | 0.06 |
| hsCRP (mg/L) | 0.7 (0.4, 1.2)† | 2.0 (0.5, 5.4) | 1.2 (0.4, 3.2) | 2.5 (1.2, 6.4) | 0.003 |
| eGDR (mg/kg/min) | 10.5 ± 2.1†,‡ | 7.4 ± 2.5 | 8.9 ± 1.7 | 5.7 ± 2.1‡ | <0.0001 |
| Smoking (current/ex/never) | 3/10/19a | 12/15/39a | 10/6/18a | 2/9/21a,‡ | 0.07 |
| Retinopathy (Y/N/only) | – | 28/41/8 | – | 28/6/8 | – |
| Nephropathy (Y/N/only) | – | 26/43/6 | – | 26/8/6 | – |
|
| |||||
| miR-142 | Non-diabetic | All T1D | T1D-No Cx |
T1D-Cx | Pb |
|
| |||||
| miR-142 (raw) (mean ± SD) | 1.25 ± 0.78† | 3.53 ± 3.66 | 2.68 ± 2.14 | 4.40 ± 4.62‡ | 0.0002 |
| miR-142 (raw) (median (LQ, UQ)) | 1.03 (0.77, 1.68)†,‡ | 2.61 (0.93, 5.19) | 2.21 (0.80, 3.57) | 3.00 (1.16, 6.05) | 0.0002 |
| Adjusted(1) miR-142 (mean, 95% CI) |
0.67 (−0.89, 2.24)† | 3.99 (2.79, 5.19) | 3.12 (1.80, 4.44) | 4.44 (3.02, 5.85) | 0.01 |
| Adjusted(2) miR-142 (mean, 95% CI) |
0.97 (−0.43, 2.37)† | 3.94 (2.80, 5.08) | 2.95 (1.73, 4.16) | 4.85 (3.58, 6.12) | 0.0006 |
BOLD p < 0.05 Non-diabetic vs. All T1D.
Adjusted (1): BP, HbA1c, TC, LDL, eGFR, hsCRP, eGDR, Adjusted (2): Age, Sex, HbA1c.
a
Some data missing.
b
Non-diabetic vs. T1D-No Cx vs. T1D-Cx: ANOVA, Kruskal-Wallis ANOVA or χ2.
‡
p < 0.05 vs. T1D-No Cx.
†
p < 0.05 vs. T1D-Cx.