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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Thromb Haemost. 2023 Aug 23;21(11):3005–3015. doi: 10.1016/j.jtha.2023.08.014

Figure 1. Fibrinogen structure.

Figure 1.

A) Fibrinogen is encoded by 3 genes (FGA, FGB, and FGG) clustered within a 65 kilobase region on human chromosome 4 (4q23-q32). FGA and FGG are in opposite orientation to FGB on the chromosome. CCCTC-binding factor (CTCF) interaction sites flank the fibrinogen gene cluster direct chromatin looping and enable coordinate transcription of the fibrinogen genes. B) Fibrinogen is a 340-kDa hexameric glycoprotein containing 2 each of 3 polypeptide chains: Aα (red), Bβ (blue), and γ (green). The 6 fibrinogen polypeptides are arranged with N-termini in a central E region and C-termini radiating outwards with bilateral symmetry.