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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Thromb Haemost. 2023 Aug 23;21(11):3005–3015. doi: 10.1016/j.jtha.2023.08.014

Figure 4. Fibrin crosslinks introduced by factor XIII.

Figure 4.

Activated factor XIII (FXIIIa) introduces covalent bonds (“X”) between fibrin γ chains (generating γ-γ dimers), between γ- and α-chains (generating α-chain-rich high molecular weight species), and between fibrin chains and other plasma proteins (e.g., α-chain:α2-antiplasmin [AP]).