Table 2.

Summary of parametric survival generalized gamma models for elementary, partially enriched and fully enriched models, including coefficients and model fit statistics. The unit of analysis were models with model fit and calibration described at the bottom.

		Partially enriched models
Parameter	Elementary (eGFR, UPCR, diagnosis only)	PE Model 1 (Elementary + BP + ΔGFR)	PE Model 2 (Elementary + BP + Anemia)	PE Model 3 (Elementary + BP + lab values)	PE Model 4 (Elementary + BP + Anemia + lab values)	Enriched (All predictors)
β
Intercept	2.8624	2.8993	2.9967	3.7450	4.4095	4.4493
Per 1 log increase in (eGFR/45)	2.0868	1.9511	1.9769	2.1789	2.0944	1.9837
Per 1 log increase in (eGFR/45)×(eGFR ≥ 45)	−1.0758	−1.0091	−1.1370	−1.3874	−1.4511	−1.4158
Glomerular non-HUS vs. Non-glom/HUS	−0.1532	−0.0718	−0.0511	−0.1071	−0.0231	0.0268
Per 1 log increase in (eGFR/45) × Glom non-HUS	1.0386	0.8132	0.9807	0.6812	0.7360	0.6275
Per 1 log increase in (eGFR/45)×(eGFR ≥ 45) × Glom non-HUS	−1.2154	−1.0010	−1.0714	−0.5795	−0.6282	−0.5253
Per 1 log increase in (UPCR/0.5)	−0.1959	−0.2123	−0.2127	−0.1720	−0.1984	−0.1968
Per 1 log increase in (UPCR/0.5) × (UPCR ≥ 0.5)	−0.3146	−0.2721	−0.2566	−0.2102	−0.1803	−0.1759
Elevated BP/hypertension vs. normal BP		−0.2229	−0.2337	−0.2242	−0.2339	−0.2282
Per 1 increase in Δ( log(eGFR)) per year		0.4349				0.3934
Anemia vs. no anemiaa			−0.3617		−0.3162	−0.3033
Per 1 unit increase in albumin, mg/dLb				0.3802	0.3168	0.3172
Per 1 unit increase in chloride, mmol/Lb				−0.0235	−0.0248	−0.0255
Per 1 unit increase in CO2, mmol/Lb				0.0005	−0.0074	−0.0071
σ
Intercept	0.7440	0.7454	0.7441	0.7204	0.7242	0.7262
Glomerular non-HUS vs. Non-glom/HUS	0.2627	0.1744	0.2521	0.2426	0.2172	0.1390
K
Intercept	0.4253	0.3888	0.3513	0.4467	0.4163	0.3914
Glomerular non-HUS vs. Non-glom/HUS	−0.0005	0.2204	0.1023	0.0768	0.1367	0.2787
Model fit and calibration
AIC	1476.48	1470.09	1457.68	1456.72	1446.15	1445.06
Likelihood ratio test
Compared to elementary	Ref	0.006	<0.001	<0.001	<0.001	<0.001
Compared to enriched	<0.001	<0.001	<0.001	<0.001	0.080	Ref
Optimism-corrected c-statistic	0.865	0.866	0.874	0.871	0.875	0.875
Greenwood-Nam-D’Agostino test statistic
At 2 years with 4 bins (${\chi }_3^2$)	2.201	2.213	2.237	2.318	1.526	1.903
p-value	0.53	0.53	0.52	0.51	0.68	0.59
At 5 years with 6 bins (${\chi }_5^2$)	4.123	5.022	4.827	4.231	3.518	2.643
p-value	0.53	0.41	0.44	0.52	0.62	0.75

^aAnemia defined as current low hemoglobin.

^bLaboratory-measured serum biomarkers from renal panel.