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Inhibition of poly(Phe) synthesis by GM193663 in extracts from wild-type and resistant strains. Cell extracts from mutants belonging to complementation groups 1 (FPR1) and 2 (FPR2) and from their corresponding parental strains were programmed with poly(U) to synthesize poly(Phe) in the presence of various concentrations of GM193663, as described in Materials and Methods. Data from two independent experiments are represented together. •, resistant mutant; ○, wild-type parental strain.
