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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Trends Neurosci. 2023 Sep 19;46(11):941–952. doi: 10.1016/j.tins.2023.08.007

Figure 3: Recovery of dopamine transporter binding six months after DA stem cell transplantation in the rat striatum in a 6-hydroxy-dopamine model of PD.

Figure 3:

(A) A naive rat showed bilaterally symmetrical uptake of [18F]FECNT, a radioligand for the dopamine transporter. (B) Unilateral injection of a dopaminergic toxin created a hemiparkinsonian rat, which displayed negligible [18F]FECNT uptake in the lesioned striatum. (C) ES cell transplantation partially restored uptake of [18F]FECNT in the lesioned striatum. (D) Coregistered PET and MR images after ES-cell transplantation. In this example, PET imaging of the dopamine transporter was used as a PET reporter system to monitor the survival and growth of transplanted cells. Figure adapted from [71].