Figure 4. Liver and muscle diurnal transcriptomes are influenced by Bmal1 function in distal tissues.
(A and B) dryR analysis of RNA-seq of gastrocnemius muscle (A) and liver (B) harvested around the clock, 12 h light: 12 h dark conditions, n = 3. ZT, zeitgeber time; ZT0, lights on; ZT12, lights off. Left, polar histogram, peak phases. Middle, DAVID biological process enrichments, some pathway names abbreviated. Right, heatmaps of group averages sorted by WT peak phase. Top, genes oscillating exclusively in WT and Liver+Muscle-RE. Bottom, genes oscillating exclusively in WT.