Table 4.

Sensitivity Analysis: 3:1 (Gabapentin:Duloxetine) Matched Analysis

		Gabapentin (N Prescriptions: 288,531)			Duloxetine (N Prescriptions: 91,177)			Cox Proportional Hazards Analysis
Outcome	Concurrent MME	N Events	Person-Years	Rate per 1,000 person-years	N Events	Person-Years	Rate per 1,000 person-years	Hazard Ratio (95% CI)
All-Cause Mortality	No MME (MME = 0)	243	22505	10.80	83	8051	10.31	1.06 (0.83, 1.36)
	Low MME (MME >0 & MME < 50)	60	3698	16.22	20	1289	15.52	1.05 (0.63, 1.74)
	High MME (MME ≥ 50)	25	2091	11.96	<11	744	9.40	1.30 (0.56, 3.01)
Out of Hospital Mortality	No MME (MME = 0)	127	22402	5.67	34	8014	4.24	1.33 (0.91, 1.95)
	Low MME (MME >0 & MME < 50)	40	3671	10.90	13	1281	10.15	1.07 (0.57, 2.00)
	High MME (MME ≥ 50)	20	2076	9.63	<11	739	5.41	1.82 (0.62, 5.34)

CI=confidence interval, MME= Morphine Milligram Equivalents

Duloxetine is the reference for all Hazard Ratios