Figure 2.

Increased α-tryptase isoform expression is associated with increased severity of reaction to peanut oral food challenge (OFC). A. Subjects with any α-tryptase isoforms were more likely to have higher Severity Grading Score for Acute Reactions (SGSAR) scores as compared to subjects with no α-tryptase isoforms. B. There was a statistically significant positive correlation between α-tryptase isoform copy numbers and total modified Bock/PRACTALL symptom score. Wilcoxon tests assessed for association between presence of any α-tryptase and OFC scores; Spearman’s rank correlation was also performed between total number of α-tryptase isoforms and SGSAR to assess for possible gene dosage effects.