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. Author manuscript; available in PMC: 2024 Apr 2.
Published in final edited form as: Mol Cancer Ther. 2023 Oct 2;22(10):1182–1190. doi: 10.1158/1535-7163.MCT-22-0818

Figure 4. Irradiation induces PTGR1 expression and sensitizes tumors to LP-184.

Figure 4.

(A) Higher PTGR1 mRNA expression in KEAP1-mutated lung cancer cell lines. p-value, t-test. (B) Doxycycline-induced NRF2 expression is associated with increased PTGR1 in Panc1 cells as assessed by Western blot of total cell lysates collected at the indicated time points. (C) PTGR1 expression 2 hours following a single dose of 8 Gy of irradiation. Mock, cells were handled under the identical condition, except not irradiated. (D) Timing of PTGR1 expression in vivo in Panc 03.27 xenografts following a single dose of 4 Gy of irradiation. (E) Relative Tumor Volumes (RTV) normalized to the baseline of Panc 03.27 hind limb xenografts treated with 3 weekly intraperitoneal doses of LP-184 at 3 mg/kg or PBS vehicle, either alone, or in combination with 4 Gy of radiation (arrowheads). (F) Weights of xenografted tumors on Day 21 normalized to the initial pre-treatment estimated volumes; p-values: a linear mixed effects model was used to test difference in slopes of volume and the tumor weights.