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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Trends Mol Med. 2023 Sep 4;29(11):939–950. doi: 10.1016/j.molmed.2023.08.002

Figure 3.

Figure 3.

Sushi, von Willebrand factor type A, epidermal growth factor and pentraxin domain containing 1 (SVEP1) throughout life. SVEP1 and the antagonistic pleiotropy theory of aging. SVEP1 is essential for embryonic viability and appears to promote age-related disease later in life. This can be explained by the theory of antagonistic pleiotropy, which states that alleles necessary for development and reproduction are favored without regard for their effects in later life. The loss of selective pressure on alleles during the period proceeding max reproductive capability is referred to as the selection shadow.