FIG. 1.
Single-dose plasma pharmacokinetics of BMS 181184. (a) Concentration-versus-time curves after administration of 10, 25, 50, and 150 mg of the compound/kg. Each point plots the mean level for three rabbits each at that time. (b) Plot of the AUC0–24/dose ratios for each rabbit and the mean ± the standard error of the mean (SEM) for each dosage group. For a drug that follows linear kinetics, such a plot would have a slope of 0. For BMS 181184, however, the significantly negative slope of the means (P < 0.001; ANOVA) is indicative of the compound’s nonlinear kinetics.