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AUC0–24 values at the four investigated dosage levels after single-dose and multiple-dose administration of BMS 181184 (mean values for three rabbits each ± standard errors of the means [SEM]). Note the decrease in the AUC0–24 after multiple once-daily dosing at 150 mg/kg compared to the next-lower dosage level (∗, P < 0.01; Student’s t test) and compared to the AUC0–24 obtained after one single dose of 150 mg/kg (∗, P < 0.05; Student’s t test).
