TABLE 1.

Single-dose pharmacokinetics of BMS 181184 in plasma^a

Drug dose (mg/kg)	Cmaxb (μg/ml)	Cmin (μg/ml)	AUC0–24b (μg · h/ml)	Vc (liter/kg)	V1 (liter/kg)	Vp (liter/kg)	CLTd (liter/h)	CLDe (liter/h)	t1/2α (h)	t1/2βf (h)
10	120 ± 7	5 ± 0.5	726 ± 40	0.397 ± 0.019	0.244 ± 0.013	0.153 ± 0.017	0.058 ± 0.005	0.361 ± 0.140	0.221 ± 0.062	4.99 ± 0.71
25	218 ± 11	8 ± 0.5	1,120 ± 44	0.506 ± 0.038	0.315 ± 0.098	0.191 ± 0.067	0.103 ± 0.009	0.610 ± 0.276	0.148 ± 0.050	3.50 ± 0.08
50	312 ± 4	5 ± 0.8	1,551 ± 146	0.545 ± 0.039	0.366 ± 0.033	0.179 ± 0.006	0.097 ± 0.009	0.270 ± 0.062	0.341 ± 0.105	4.08 ± 0.08
150	648 ± 9	9 ± 1.1	2,130 ± 167	0.799 ± 0.056	0.404 ± 0.037	0.395 ± 0.093	0.259 ± 0.023	0.902 ± 0.194	0.142 ± 0.019	2.31 ± 0.21

^aAll values are expressed as means ± standard errors of the means. 

^bP < 0.001 by Kruskal-Wallis nonparametric ANOVA. 

^cP < 0.005 by Kruskal-Wallis nonparametric ANOVA; 150 versus either 10, 25, or 50 mg/kg, P < 0.05 by the Student t test. 

^dP < 0.001 by Kruskal-Wallis nonparametric ANOVA; 25 or 50 versus 10 mg/kg, P < 0.05, and 150 versus 50 or 25 mg/kg, P < 0.01, both by the Student t test. 

^e150 versus 50 mg/kg, P < 0.05 by the Student t test. 

^fP < 0.001 by Kruskal-Wallis nonparametric ANOVA; 150 versus either 10, 25, or 50 mg/kg, P < 0.05 by the Student t test.