TABLE 2.

Pharmacokinetics of BMS 181184 in plasma after multiple dosing over 15 days^a

Drug dose (mg/kg · day)	Cmaxb (μg/ml)	Cmin (μg/ml)	AUC0–24c (μg · h/ml)	Vd (liter/kg)	V1 (liter/kg)	Vpe (liter/kg)	CLTf (liter/h)	CLDg (liter/h)	t1/2αh (h)	t1/2βi (h)
10	116 ± 6	9 ± 4.0	816 ± 63	0.508 ± 0.076	0.273 ± 0.019	0.235 ± 0.079	0.049 ± 0.003	0.361 ± 0.099	0.229 ± 0.020	7.33 ± 1.26
25	198 ± 8	8 ± 1.5	1,298 ± 83	0.672 ± 0.129	0.472 ± 0.054	0.200 ± 0.076	0.082 ± 0.009	0.143 ± 0.019	0.617 ± 0.100	6.00 ± 0.62
50	366 ± 24	15 ± 3.2	1,911 ± 55	0.497 ± 0.071	0.312 ± 0.023	0.185 ± 0.093	0.080 ± 0.010	0.351 ± 0.274	0.563 ± 0.282	5.00 ± 1.38
150	662 ± 23	26 ± 4.4	1,385 ± 81	1.013 ± 0.133	0.348 ± 0.034	0.665 ± 0.109	0.407 ± 0.028	0.840 ± 0.123	0.162 ± 0.041	2.21 ± 0.51

^aAll values are expressed as means ± standard errors of the means. Data of the 25-mg/kg dosage level stem from two rabbits only; in the third animal, the catheter was clogged. 

^bP < 0.001 by Kruskal-Wallis nonparametric ANOVA. 

^cP < 0.005 by Kruskal-Wallis nonparametric ANOVA; 150 versus 50 mg/kg, P < 0.01 by the Student t test. 

^d150 versus 10 or 50 mg/kg, P < 0.05 by the Student t test. 

^e150 versus 10 or 50 mg/kg, P < 0.05 by the Student t test. 

^fP < 0.005 by Kruskal-Wallis nonparametric ANOVA; 25 or 50 versus 10 mg/kg, P < 0.01, and 150 versus either 50, 25, or 10 mg/kg, P < 0.01, both by the Student t test. 

^g150 versus 25 or 10 mg/kg, P < 0.05 by the Student t test. 

^hP < 0.05 by Kruskal-Wallis nonparametric ANOVA; 25 or 50 versus either 10 or 150 mg/kg, P < 0.05 by the Student t test. 

ⁱ150 versus 10 or 25 mg/kg, P < 0.05 by the Student t test.