Table 3.
Association of cardiovascular health score with incident Alzheimer’s dementia stratified by established risk factors
| Cardiovascular Health Score (per 1-score increase) | N | Cases/PY | HR (95%CI) |
|---|---|---|---|
| Sex | |||
| Men | 653 | 138/5322.4 | 0.84 (0.7 – 1.00) |
| Women | 1049 | 213/8904.1 | 0.85 (0.75 – 0.96) |
| Race | |||
| Black or African Americans | 906 | 218/7912.9 | 0.84 (0.74 – 0.96) |
| White | 796 | 133/6313.7 | 0.84 (0.71 – 0.99) |
| Education | |||
| <=12 | 887 | 225/7462.3 | 0.88 (0.77 – 1.00) |
| >12 | 815 | 126/6764.2 | 0.80 (0.68 – 0.94) |
| APOE e4 allele | |||
| No | 1162 | 204/9764.5 | 0.83 (0.72 – 0.95) |
| Yes | 540 | 147/4462.1 | 0.87 (0.75 – 1.01) |
| Cardiovascular disease | |||
| No | 1428 | 285/12134.8 | 0.85 (0.76 – 0.96) |
| Yes | 274 | 66/2091.7 | 0.81 (0.65 – 1.00) |
Abbreviations: PY, person years; HR, hazard ratio; CI, confidence interval.
Models were adjusted by age, sex, race, education, APOE e4, cognitive activities, depression (CESD score), and cardiovascular disease (stroke and/or heart disease)