Table 4:

Association of cardiovascular health score with white matter hyperintensity, hippocampus, and gray matter volumes

Cardiovascular Health Score	N	Mean	Beta	95%CI
White matter hyperintensity
Continuous
Per 1-point increase	671	0.788	−0.028	−0.05, −0.005
Categorical
0–6	140	0.871	0	reference
7–9	367	0.769	−0.134	−0.242, −0.026
10–14	164	0.757	−0.142	−0.272, −0.012
Hippocampus
Continuous
Per 1-point increase	671	0.692	0.001	−0.001, 0.003
Categorical
0–6	140	0.69	0	reference
7–9	367	0.694	0.013	0.002, 0.024
10–14	164	0.69	0.01	−0.002, 0.023
Gray matter
Continuous
Per 1-point increase	671	2.549	0.002	0.001, 0.004
Categorical
0–6	140	2.546	0	reference
7–9	367	2.548	0.007	0.002, 0.013
10–14	164	2.554	0.013	0.007, 0.02

White matter hyperintensities and hippocampal volumes were corrected for intracranial volume, multiplied by 1000, and log10-transformed to normalize the data. Means showed in the table are age-adjusted.

Regression models were adjusted by age, sex, race, education, and APOE e4, and time from cardiovascular health to MRI assessments.