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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jun 9;42(6):112574. doi: 10.1016/j.celrep.2023.112574

Figure 5. M1 cell-type- and layer-specific firing dynamics during quiet and movement states for MTh inactivation and NA-R-block conditions.

Figure 5.

(A and D) Top: raster plot of activity transitioning from quiet (1 s) to movement (2 s) (3 s of base model simulation shown; cells grouped by population and ordered by cortical depth within each population). Bottom: example model PT5B (blue) and experiment (black) voltage traces.

(B and E) Firing rate (mean, SD) in different cell populations for the original model set (blue), modified model (purple), and experiment (orange). The modified model decreased long-range inputs from cM1 and M2 for the MTh inactivation condition and increased K+ conductance for the NA-R-block condition. The original model set includes cell rates of all 25 simulations; the mean rates of each individual simulation are shown as thin blue lines. Statistics were computed across 4 s for each state.

(C and F) Low-dimensional representation (UMAP) of the firing rates of 1,000 randomly selected neurons during the control condition quiet (0–2 s; blue) and movement (2–4 s; red) states and the MTh inactivation/NA-R-block condition quiet (light blue/green) and movement (purple/orange) states. Each dot represents activity within a 25-ms time bin; start and end points indicated with larger dots; behavior transition point indicated with black border.