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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Gastroenterology. 2023 Jul 26;165(5):1276–1279.e7. doi: 10.1053/j.gastro.2023.07.015

Figure 1: Germline Mutational Landscape Across Esophageal Adenocarcinoma.

Figure 1:

(A) Clinical characteristics of study participants from public genomic and MGH cohorts. ICGC-ARGO refers to International Cancer Genome Consortium Project Accelerating Research in Genomic Oncology; Broad/MSKCC Cohort refers to the pooled public exomes of esophageal adenocarcinoma available on dbGAP; TCGA refers to The Cancer Genome Atlas; Wellderly refers to healthy nonagenarians without history of gastrointestinal neoplasia. (B) Number of pathogenic mutations itemized by cancer-predisposing genes across multiple cohorts. Color-coding of entries demonstrates carrier-frequency in their respective cohorts. (C) Histogram showing the age at diagnosis of Barrett’s esophagus with high-grade dysplasia or esophageal adenocarcinoma. Mutation carriers and non-carriers are color-coded by blue and gray, respectively. (D) Correlation of germline pathogenic mutations with somatic TP53 status in tumors, segregated by exomes and genomes. (E) Correlations between individual genes mutated in the germline and somatic TP53 status. *** designates P < 0.001 and * designates P = 0.06.