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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Mod Pathol. 2023 Jun 19;36(10):100241. doi: 10.1016/j.modpat.2023.100241

Table 2.

Univariable Cox’s proportional hazards analysis of AI-qPTEN and other post-surgical variables with recurrence- and metastasis-free survival. cPTEN: Conventional visual scoring, AI: Artificial Intelligence, AI-qPTEN: AI-based quantitative PTEN loss, CAPRA-S: Cancer of the Prostate Risk Assessment (CAPRA) post-surgical score, HR: Hazard Ratio, CI: Confidence Interval

Recurrence-free Survival Metastasis-free Survival
Characteristic N HR1 95% CI1 p-value N HR1 95% CI1 p-value
Grade Group (GG) 986 983
1 — — — —
2 1.36 1.09, 1.71 0.007 2.42 1.52, 3.85 <0.001
≥3 2.39 1.89, 3.03 <0.001 5.03 3.18, 7.95 <0.001
preopPSA 895 1.04 1.03, 1.04 <0.001 892 1.02 1.01, 1.03 <0.001
Seminal Vesicle Invasion (SVI) 983 981
Absent — — — —
Present 2.98 2.25, 3.96 <0.001 2.32 1.44, 3.72 <0.001
Surgical Margin 960 959
Absent — — — —
Present 1.92 1.58, 2.33 <0.001 1.24 0.87, 1.76 0.2
Extraprostatic Extension (EPE) 984 981
Absent — — — —
Present 1.98 1.64, 2.40 <0.001 1.56 1.11, 2.18 0.01
Lymph Node Invasion 676 673
Absent — — — —
Present 4.15 2.81, 6.14 <0.001 3.69 2.11, 6.43 <0.001
cPTEN - Binary 998 995
Intact — — — —
Loss 1.66 1.36, 2.03 <0.001 1.54 1.07, 2.21 0.019
cPTEN - Stratified 998 995
Intact — — — —
Loss - Partial 1.38 1.02,1.86 0.035 1.52 0.91, 2.54 0.11
Loss- Complete 1.89 1.49,2.39 <0.001 1.55 1.00, 2.41 0.049
AI-qPTEN - Continuous 998 2.62 1.79, 3.82 <0.001 995 4.12 2.28, 7.44 <0.001
AI-qPTEN - Categorical 998 995
Ref — — — —
High-Risk (>0.04) 1.71 1.39, 2.11 <0.001 2.55 1.83, 3.56 <0.001
CAPRA-S 594 593
Low — — — —
Intermediate 2.63 1.98, 3.50 <0.001 3.78 2.35, 6.08 <0.001
High 4.76 3.53, 6.44 <0.001 3.21 1.89, 5.44 <0.001
1

HR = Hazard Ratio, CI = Confidence Interval