Table 4:
Multivariable cox proportional hazard analysis for PTEN assessment (cPTEN and AI-qPTEN) with metastasis-free survival in patients with favorable pathologic stage and negative surgical margins (n=295). Patients are stratified as High-Risk if AI-qPTEN results in >0.04 proportion of cancer burden contained PTEN loss by AI assessment. For cPTEN analysis, patients were stratified as PTEN Intact (PTEN loss=0%) or PTEN Loss (PTEN loss>0%). cPTEN: Conventional visual scoring, AI: Artificial Intelligence, AI-qPTEN: AI-based quantitative PTEN loss, CAPRA-S: Cancer of the Prostate Risk Assessment (CAPRA) post-surgical score, HR: Hazard Ratio, CI: Confidence Interval
| With cPTEN | With AI-qPTEN | |||||
|---|---|---|---|---|---|---|
| Characteristic | HR1 | 95% CI1 | p-value | HR1 | 95% CI1 | p-value |
| Grade Group (GG) | ||||||
| 1 | — | — | — | — | ||
| 2 | 2.9 | 1.22, 6.92 | 0.016 | 2.62 | 1.10, 6.25 | 0.03 |
| 3+ | 4.8 | 1.89, 12.2 | <0.001 | 4.26 | 1.68, 10.8 | 0.002 |
| pre-Op PSA | 1.07 | 1.03, 1.11 | <0.001 | 1.07 | 1.03, 1.11 | <0.001 |
| cPTEN | ||||||
| Intact | — | — | ||||
| Loss | 1.43 | 0.72, 2.82 | 0.3 | |||
| AI-qPTEN | ||||||
| Ref | — | — | ||||
| High-Risk (>0.04) | 2.72 | 1.46, 5.06 | 0.002 | |||
| Concordance Index | 0.713 | 0.743 | ||||
1
HR = Hazard Ratio, CI = Confidence Interval