. Author manuscript; available in PMC: 2024 Apr 2.

Published in final edited form as: Cancer Prev Res (Phila). 2023 Oct 2;16(10):561–570. doi: 10.1158/1940-6207.CAPR-23-0112

Table 1.

Analysis of associations between smoking status and FGFR3-Y375C, FGFR3-S249C, and PIK3CA- E542K/E545K mutations

FGFR3 Mutation	Smoking Status^*	Total	FGFR3-Y375C, N=217^†		FGFR3 other mutations, N=832^†		FGFR3-WT, N=1758^†		FGFR3-Y375C
			FGFR3-Y375C, N=217^†		FGFR3 other mutations, N=832^†		FGFR3-WT, N=1758^†		Compared to other FGFR3 mutations		Compared to FGFR3-WT
			n	%	n	%	n	%	Adjusted OR (95% CI)^§	P	Adjusted OR (95% CI)^§	P
Y375C	Never	647	27	4.2	171	26.4	447	69.1	Ref		Ref
	Ever	2056	181	8.8	610	29.7	1260	61.3	1.84 (1.17 – 2.91)	0.009	1.86 (1.19 – 2.92)	0.007
	Never	647	27	4.2	171	4.2	447	26.4	Ref		Ref
	Former	973	90	9.2	311	9.2	570	32.0	1.89 (1.14 – 3.14)	0.014	1.86 (1.12 – 3.09)	0.016
	Current	665	74	11.1	229	11.1	359	34.4	2.01 (1.20 – 3.38)	0.008	2.02 (1.20 – 3.40)	0.008
FGFR3 Mutation	Smoking Status^*	Total	FGFR3-S249C, N=622^†		FGFR3 other mutations, N=427^†		FGFR3-WT, N=1758^†		FGFR3-S249C
			FGFR3-S249C, N=622^†		FGFR3 other mutations, N=427^†		FGFR3-WT, N=1758^†		Compared to other FGFR3 mutations		Compared to FGFR3-WT
			n	%	n	%	n	%	Adjusted OR (95% CI)^§	P	Adjusted OR (95% CI)^§	P
S249C	Never	647	132	20.4	66	10.2	447	69.1	1.54 (1.10 – 2.18)	0.013	1.05 (0.81 – 1.37)	0.685
	Ever	2056	455	22.1	336	16.3	1260	61.3	Ref		Ref
	Never	647	132	20.4	66	20.4	447	10.2	1.61 (1.08 – 2.40)	0.020	1.05 (0.76 – 1.46)	0.755
	Former	973	233	23.9	168	23.9	570	17.3	1.09 (0.80 – 1.49)	0.581	1.00 (0.76 – 1.30)	0.985
	Current	665	171	25.7	132	25.7	359	19.8	Ref		Ref
PIK3CA Mutation	Smoking Status^*	Total	PIK3CA- E542K/E545K, N=280^†		PIK3CA other mutations, N=193^†		PIK3CA-WT, N=1499^†		PIK3CA-E542K/E545K
			PIK3CA- E542K/E545K, N=280^†		PIK3CA other mutations, N=193^†		PIK3CA-WT, N=1499^†		Compared to other PIK3CA mutations		Compared to PIK3CA-WT
			n	%	n	%	n	%	Adjusted OR (95% CI)^§	P	Adjusted OR (95% CI)^§	P
E542K or E545K	Never	499	88	17.6	44	8.8	366	73.3	1.81 (1.17 – 2.82)	0.009	1.54 (1.15 – 2.07)	0.004
	Ever	1369	175	12.8	142	10.4	1048	76.6	Ref		Ref
	Never	499	88	17.6	44	17.6	366	8.8	2.44 (1.24 – 4.80)	0.010	1.58 (1.01 – 2.47)	0.044
	Former	619	86	13.9	62	13.9	469	10.0	1.36 (0.76 – 2.40)	0.298	1.11 (0.74 – 1.66)	0.624
	Current	332	45	13.6	36	13.6	249	10.8	Ref		Ref

WT, wild-type;

Ever-smokers include former, current and occasional smokers;

^†

See Table S1 for detailed information;

^§

Odds ratios (ORs) and 95% confidence intervals (CIs) are calculated using polytomous logistic regression models, adjusting for study, tumor stage (Ta, T1, T2+), and sex.