Table 2.

Summary of polyomavirus positivity and APOBEC-type driver mutation positivity among BC samples

Subset	Total	Samples positive for PyV
	n	n	%	p-val
Total BC	1010	26	2.6	na
NMIBC	554	25	4.5	4.4E-05
NMIBC with FGFR3 or PIK3CA mutation	398	19	4.8	na
MIBC	456	1	0.2	Ref
Subset: NMIBC with FGFR3 or PIK3CA mutation	Total	Samples positive for APOBEC-type driver mutation (FGFR3-S249C, PIK3CA-E545K, or PIK3CA-E542K)
	n	n	%	p-val
BKPyV+	19	18	94.7	0.011
BKPyV−	379	259	68.3	Ref

BC, bladder cancer; BKPyV, BK polyomavirus; NMIBC, non-muscle invasive bladder cancer; PyV, polyomavirus.