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. Author manuscript; available in PMC: 2024 Oct 9.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Aug 17;62(41):e202307210. doi: 10.1002/anie.202307210

Scheme 2.

Scheme 2.

CyClick reaction on linear peptide aldehyde a) 18 (AAGPFA) selectively generates a 15-membered imidazolidinone cyclic peptide 20; b) 21 (AFPA) does not generate 9-membered imidazolidinone cyclic peptide 23