| Lips P et al. |
400lU/d |
3.5 years |
270 |
Netherlands: Women and Men >70 years [baseline 25(OH)D 10.6 ng/mL]
|
400 lU/day of vitamin D increased BMD at the femoral neck by 2.3%
|
| Macdonald HM et al. |
400 IU or 1000lU/d |
1 year |
305 |
Scotland: Women aged 60–70 years [baseline 25(OH)D 13.5 ng/mL]
|
1,000 lU/day of vitamin D prevented bone loss of ~0.6% at the hip but not at the spine |
| Hansen KE et al. |
Daily 800 IU or twice monthly 50,000 IU |
1 year |
230 |
US: Women <75 years [baseline 25(OH)D 21 ng/mL]
|
No effect on BMD Preselected for vitamin D insufficiency |
| Reid IR et al. |
100,000 lU/month |
2 years |
452 |
New Zealand (VIDA): Community dwelling older adults [baseline 25(OH)D 22 ng/mL]
|
Attenuated bone loss at the hip by 0.5%; No meaningful effect on BMD
|
| LeBoff etal. |
Daily 2000 IU |
5.3 years |
771 |
US (VITAL): Women aged >55 years and men aged >50 years [baseline 25(OH)D 30.7 ng/mL]
|
No effect on aBMD at spine, hip, or whole body or vBMD at radius or tibia or measures of bone structure |
