Table 1.

Demographics and clinical data, cardiac MRI, and resting hemodynamics by assessment time by PAH or control cohorts.

		PAH (n=63)			Control (n=62)
		Baseline	Follow-up	P-value*		P-value†
Age (years)		51.2±12.7			50.0±14.02	0.31
Sex (N/% Female)		51 (81)			49 (79)	0.82
BMI (kg/m2)		31.0±8.3			27.3±5.3	0.003
Ethnicity (N/% Hispanic)		18 (28)			14 (23)	0.13
	6 Minute Walk Distance (M)	284[115,362]	355[204,434]	<0.001	547[479,600]	<0.001
	BNP (pg/dL)	503[127.5,852.5]	70[27,155]	<0.001	52[28.5,89.0]	<0.001
Cardiac MRI	RVEDVI (mL/m2)	110.1[92.2,136.1]	100.8[80.7,128.0]	0.12	69.8[59.2,78.8]	<0.001
	RVESVI (mL/m2)	77.6[60,103.8]	63.6[51.9,85.1]	<0.001	29.9[23.8,36.1]	<0.001
	RVEF (%)	27.4±9.3	35.0±9.8	<0.001	57.12±7.29	<0.001
	RV Mass (gm/m2)	46.1±15.2	45.0±22.8	0.65	10.8±3.4	<0.001
	RV Mass/EDV (gm/mL)	0.41±0.12	0.41±0.14	1.0	0.17±0.05	<0.001
Hemodynamics	RAP (mmHg)	11±7	4±4	<0.001
	mPAP (mmHg)	55.4±10.4	39.2±9.5	<0.001
	PCWP (mmHg)	9.2±4.4	7.3±3.1	<0.001
	Cardiac Index (L/min/m2)	2.02±0.63	2.9±0.99	<0.001
	PVR (WU)	11.8[9.45,15.9]	6.1[4.79,7.98]	<0.001
	Compliance (mL/mmHg)	0.99[0.77,1.35]	1.74[1.30,2.33]	<0.001
	PA Elastance (mmHg/mL)	1.52[1.19,1.99]	0.89[0.70,1.28]	<0.001

Values are mean ± SD, median [P25,P75], or N (%). BMI, body mass index; BNP, brain natriuretic peptide; MRI, magnetic resonance imaging; RVESVI, right ventricular end-systolic volume index; RVEDVI, right ventricular end-diastolic volume index; RVEF, right ventricular ejection fraction; PAP, pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; RAP, right atrial pressure; PVR, pulmonary vascular resistance. P values calculated as follows: Kruskal-Wallis test for continuous and ordinal variables or Wilcoxon signed-rank non-parametric test for related samples, Fisher exact test for categorical variables.

^*P-value within PAH follow-up versus baseline;

^†P value control versus PAH at follow-up.