Table 3.
Longitudinal Cardiac MRI features of the RV functional recovery (RVFnRec) and no recovery (No RVFnRec) cohorts.
| Baseline | Follow-Up | Mean Change | Relative Change | P-value* | Baseline | Follow-Up | Mean Change | Relative Change | P-value* | P-Value† | P-Value‡ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
RVEDVI
(mL/m2) |
119.5 [104.0,145.7] |
92.3 [75.5,102.7] |
−34.5±24.6 | −25.5±14.1 | <0.001 | 105 [87.5,131.8] |
114.0 [88.2,159.0] |
8.7±26.5 | 9.0±26.8 | 0.04 | <0.001 | <0.001 |
|
RVESVI
(mL/m2) |
92.3 [74.5,105.1] |
35.5 [31.0,40.0] |
−37.6±18.2 | −39.6±13.3 | <0.001 | 71.2 [57.4,101.9] |
73.2 [57.5,123.8] |
1.6±25.1 | 6.2±37.7 | 0.88 | <0.001 | <0.001 |
| RVEF (%) | 26.6±6.7 | 43.0±7.4 | 15.7±7.1 | 55.7±35.9 | <0.001 | 27.7±10.3 | 32.0±8.7 | 4.4±11.0 | 32.4±62.8 | 0.02 | <0.001 | 0.12 |
|
RVMI
(gm/m2) |
44.6 [34.1,51.3] |
35.4 [29.8,40.5] |
−1.1±28.2 | −2.1±41.0 | 0.12 | 50.0 [29.4,60.5] |
43.9 [33.0,59.2] |
−1.2±13.0 | 0.2±30.6 | 0.50 | 0.94 | 0.89 |
|
RV M/V
(gm/mL) |
0.4 [0.3,0.52] |
0.37 [0.33,0.45 |
0.1±0.1 | 22.0±33.7 | 0.45 | 0.42 [0.3,0.6] |
0.34 [0.30,0.50] |
−0.04±0.1 | −7.2±22.8 | 0.61 | 0.06 | 0.07 |
| RV SV/ESV | 0.37±0.1 | 0.72±0.3 | 0.34±0.2 | 98.0±66.8 | <0.001 | 0.41±0.2 | 0.5±0.2 | 0.1±0.2 | 51.4±93.9 | 0.04 | <0.001 | 0.04 |
|
LVEDVI
(mL/m2) |
47.5 [44.8,59.7] |
66.3 [51.5,75.9] |
10.7±16.9 | 28.6±44.3 | 0.006 | 49.0 [39.5,54.9] |
63.8 [55.1,76.2] |
16.8±15.4 | 35.4±32.4 | <0.001 | 0.22 | 0.56 |
|
LVESVI
(mL/m2) |
25.0 [17.1,26.9] |
26.6 [17.7,36.4] |
1.7±9.9 | 12.6±46.0 | 0.21 | 22.0 [15.3,27.8] |
26.6 [23.2,32.8] |
8.3±9.3 | 46.8±52.4 | <0.001 | 0.02 | <0.001 |
| LVEF (%) | 54.0 [46.2,61.3] |
56.8 [54.8,68.3] |
7.2±9.9 | 15.6±19.9 | 0.01 | 54.0 [46.9,67.3] |
57.1 [53.3,60.8] |
−1.3±11.5 | −0.2±19.8 | 0.68 | 0.01 | 0.01 |
|
LVMI
(gm/m2) |
36.8±6.1 | 42.4±26.3 | 22.0±5.1 | 62.3±13.2 | 0.28 | 45.0±16.9 | 42.3±18.7 | −3.5±19.8 | 1.1±52.0 | 0.73 | 0.12 | 0.15 |
|
TR volume
(mL) |
3.0 [0,14.0] |
7.0 [0,21.8] |
7.6±10.9 | 0.23 | 6.0 [0,16] |
5.0 [0,16.0] |
−0.8±16.4 | 1.0 | 0.4 | |||
|
TR fraction
(%) |
0.0 [0,24.6] |
9.8 [0,33.6] |
10.1±18.5 | 0.04 | 5.0 [0,32] |
8.2 [0,27.7] |
−2.5±21.4 | 0.004 | 0.2 |
Values are mean ± SD, median [P25,P75], or N (%). RVEDVI, right ventricular end-diastolic volume index; RVESVI, right ventricular end-systolic volume index; RVEF, right ventricular ejection; RVMI, right ventricular mass index; RV M/V, right ventricular mass/volume; RV SV/ESV, right ventricular stroke volume/end-systolic volume; LVEDVI, left ventricular end-diastolic volume index; LVESVI, left ventricular end-systolic volume index; LVEF, left ventricular ejection-fraction; LVMI, left ventricular mass index; TR volume, tricuspid regurgitant volume; TR fraction, tricuspid regurgitant volume fraction (relative to stroke volume) fraction. P values calculated as follows: Wilcoxon signed-rank non-parametric test for related samples (within cohort) or repeated measures ANOVA (between cohort).
P-value for within cohort change from baseline to follow-up;
p value for between cohort change baseline to follow-up;
p-value for between group relative change (as % baseline value) baseline to follow-up.