TABLE 1.
Pharmacokinetic parameters for fed and fasting subjectsa
| Subject group | AUC (mg/liter · h) [0.45]b | Cmax (mg/liter) [0.40]c | C12 (mg/liter) [0.44]d | C24 (mg/liter) [0.45]e | Tmax (h) | t1/2 abs (h) | t1/2 elim (h) | CL (liters/h/kg) | Vss (liters/kg) |
|---|---|---|---|---|---|---|---|---|---|
| Fed | 9.08 ± 3.23 | 1.14 ± 0.58 | 0.253 ± 0.197 | 0.094 ± 0.048 | 4.68 ± 2.29 | 1.45 ± 0.70 | 6.74 ± 2.43 | 0.34 ± 0.12 | 1.94 ± 1.54 |
| Fasting | 4.08 ± 2.74 (<0.0001) | 0.46 ± 0.30 (0.003) | 0.112 ± 0.103 (0.033) | 0.042 ± 0.048 (0.001) | 3.89 ± 1.78 (NS) | 1.16 ± 1.02 (NS) | 4.38 ± 1.90 (0.019) | 0.34 ± 0.12 (NS) | 1.54 ± 3.41 (NS) |
a
Values are means ± SD. Values in brackets are ratios of parameter values for the fasting group to those for the fed group. Values in parentheses are P values derived from a comparison of the fed and fasting groups; NS, not significant. C12 and C24, plasma concentrations at 12 and 24 h, respectively; t1/2 abs, absorption half-life; t1/2 elim, elimination half-life.
b
90% confidence interval (CI90), 0.24 to 0.58.
c
CI90, 0.31 to 0.64.
d
CI90, 0.02 to 0.87.
e
CI90, 0.13 to 0.78.