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. Author manuscript; available in PMC: 2024 Oct 18.
Published in final edited form as: Neuron. 2023 Aug 4;111(20):3176–3194.e7. doi: 10.1016/j.neuron.2023.07.005

Figure 3: Acute γ-secretase inhibition does not impair synaptic transmission.

Figure 3:

(A) Acute suppression of γ-secretase activity by one-day DAPT treatment at Day 37–42 has no detectable effect on evoked EPSCs (left, representative traces; right, summary graphs of evoked EPSC amplitudes and charge transfer).

(B) Semi-acute suppression of γ-secretase activity by two-day DAPT treatment at Day 37–42 significantly decreases synaptic strength as monitored via evoked EPSCs (left, representative traces; right, summary graphs of evoked EPSC amplitudes and charge transfer).

(C) Acute suppression of γ-secretase activity by a one-day DAPT treatment at Day 20, analyzed on Day 21, has no significant effect on evoked EPSCs (left, representative traces; right, summary graphs of evoked EPSC amplitudes and charge transfer).

Data are means +/− SEM; numbers of cells/replicates are indicated in the bars. Statistical analyses were performed using two-tailed unpaired t-test, with * = p<0.05; ** = p<0.01, *** = p<0.001. For kinetics and intrinsic properties, see Figure S5.