Table 1:
Clinicopathologic Features of Our Cases
| Case | Age, Sex | Symptom(s) | Radiologic Findings / Differential Diagnosis | Location | Size (cm) | Cellularity, Pleomorphism, Necrosis, Mitotic Count | Immunohistochemical Findings | Outcomes, Follow up (months) |
|---|---|---|---|---|---|---|---|---|
| 1 | 72, M | Abdominal pain | Solid hypervascular mass / PanNET, focal pancreatitis | Head | 5 | Low, low, no, 3/10 HPF |
Positive: STAT6, bcl-2, vimentin Negative: CD34, CD117, ALK, SMA, CMA, desmin, S100, AE1/AE3, CAM5.2, ER, PR, inhibin |
NED, 17 |
| 2 | 76, F | Back pain | Solid hypervascular mass / PanNET, less likely a thrombosed splenic artery aneurysm | Tail | 4 | Moderate, low, no, 0/10 HPF |
Positive: STAT6, bcl-2, focal SMA, focal CMA, focal ER, focal inhibin Negative: CD34, desmin, PR |
NED, 138 |
| 3 | 65, F | Incidental | Solid hypervascular mass / PanNET | Head | 4 | Low, low, no, 0/10 HPF |
Positive: STAT6, CD34 Negative: SMA, desmin, S100, ERG, CD31, CDK4, MDM2, pan cytokeratin |
NED, 42 |
| 4 | 56, M | Incidental | Cystic mass with solid component / Cystic malignancies | Head | 3.7 | Low, low, no, 0/10 HPF |
Positive: STAT6, CD34 Negative: CD117, CDK4, MDM2, ER, PR |
NED, 47 |
| 5 | 36, F | Abdominal pain | Complex cystic mass / Inflammatory conditions, SPN, mucinous neoplasms | Tail | 2.7 | Low, low, no, 0/10 HPF |
Positive: STAT6, CD34, SMA Negative: Desmin, S100 |
NED, 189 |
| 6 | 55, F | Abdominal pain | Solid hypervascular mass / Non-ductal neoplasms | Head | 3 | Low, low, no, 0/10 HPF |
Positive: STAT6, CD34, calponin Negative: CD117, DOG1, ALK, SMA, MSA, desmin, S100 |
NED, 107 |
| 7 | 57, M | Incidental | Solid hypervascular mass / N/A | Head | 0.9 | Low, low, no, 0/10 HPF |
Positive: CD34, PAX8, PAX2 Negative: CD117, DOG1, S100, pan cytokeratin, synaptophysin, chromogranin A |
NED, 3 |
| 8 | 56, M | Abdominal pain, weight loss | Solid hypervascular mass / N/A | Head | 15 | Moderate, low, focal, 1/10 HPF |
Positive: CD34, bcl-2 Negative: CD117, DOG1, SMA, CMA, desmin, S100, CD99, AE1/AE3 Non-contributory: STAT6 |
NED, 62 |
| 9 | 70, M | N/A | N/A | Tail | 13 | Low, low, no, <1/10 HPF |
Positive: STAT6, CD34, bcl-2, CD99 Negative: CD117, DOG1, SMA, desmin, S100, HMB45, CD31, ERG, EMA, Claudin, MUC4, synaptophysin, chromogranin A, ER, inhibin, WT1, calretinin |
N/A |
*
PanNET: Pancreatic neuroendocrine tumor, SPN: Solid pseudopapillary tumor, PD: Pancreaticoduodenectomy/Whipple procedure, DP: Distal pancreatectomy, SMA: Smooth muscle actin, CMA: Common muscle actin, ER: Estrogen receptor, PR: Progesterone receptor, MSA: Muscle specific actin, EMA: Epithelial membrane antigen, NED: No evidence of disease, m: months, N/A: Not available.