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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Neurochem. 2023 Aug 31;167(3):362–375. doi: 10.1111/jnc.15948

Figure 7. Calpain proteolytically cleaves N-cadherin during hyperexcitation.

Figure 7.

(A) Immunostaining of endogenous N-cadherin in cultured hippocampal neurons left unstimulated (CTRL), treated with PTX by itself, or treated with PTX in combination with calpain inhibitors as indicated. Higher magnification views of representative secondary dendrites (boxed regions) are shown below each neuron. Scale, 10 μm. (B) Quantification of images from (A) (p < 0.0001, F=9.159, DF=5) (n=36–40 neurons; one-way ANOVA and Sidak’s post-hoc test, *p<0.05, ****p<0.0001, ns=nonsignificant).