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. 2023 Jul 14;12(26):2300905. doi: 10.1002/adhm.202300905

Figure 6.

Figure 6

Evaluation of MDA‐MB‐231 human breast cancer cells behavior and phenotype in embedded bioprinted models of three different bioinks. A) MDA‐MB‐231 showed a mixture of noninvasive epithelial and mesenchymal phenotypes in all three bioinks at day 7. B) IF staining of E‐cadherin (not detected) and vimentin proteins on MDA‐MB‐231 cells in three bioinks. The cells or cell clusters with epithelial phenotypes were indicated by the all‐white arrow, while the red‐in‐white arrow represented the mesenchymal phenotypes. C) Live and dead staining of MDA‐MB‐231 cells transfected with NT and EHD2 shRNA in CH model. D) Quantification of mesenchymal phenotype ratio of two modified MDA‐MB‐231 cells in the bioprinted CH model (n = 3, *p < 0.05). Scale bar: black, 250 µm; white, 100 µm.