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. 2023 Jul 14;12(26):2300905. doi: 10.1002/adhm.202300905

Figure 7.

Figure 7

The bioprinted tumor organoids in CH bioink recapitulated in vivo tumor morphology. A) Breast tumor organoids were harvested from mice tumors. B) Left: Top view of fluorescein isothiocyanate (FITC) labeled bioink printed in the SF hydrogel support bath and side view under UV light. Right: zoomed view of organoid loaded CH bioink printed in the SF hydrogel support bath. C) Morphology of breast tumor organoids in three bioinks at day 1. D) H&E staining of breast tumor organoids at day 7 in three bioinks. E&F) IF staining of E‐cadherin and α‐SMA proteins on breast tumor organoids and mice tumor sample. G) Quantification of α‐SMA positive area ratio (area of α‐SMA positive region divided by total area of α‐SMA and E‐cadherin positive region) from organoid samples in three bioinks and the primary tumor (n = 3, *p < 0.05; NS, not significant). Scale bar: red, 5 mm; black, 250 µm; white, 100 µm.