FIG. 1.

Mean concentrations (conc) of quinupristin (Q; open square, broth; closed square, SEV) and dalfopristin (D; open circle, broth; closed circle, SEV) in broth and SEVs during the dosing regimens that took place every 8 h (a) and the high-dose (open circle, dalfopristin SEVs; closed circle, dalfopristin broth; open square, quinupristin SEVs; closed square, quinupristin broth) and low-dose (open diamond, dalfopristin broth; closed diamond, quinupristin broth) continuous infusion regimens (b). For the low-dose continuous infusion regimens, all drug concentrations in the SEVs were below the limits of detection. All data points represent mean values from at least four samples.