TABLE 2.
Summary of pharmacokinetic data (mean ± standard deviation) for quinupristin and dalfopristin in the in vitro models
| Drug and pharmacokinetic parameter | Mean ± SD results for indicated regimen
|
|||||
|---|---|---|---|---|---|---|
| Quinupristin-dalfopristin (q8h)
|
Continuous infusion
|
|||||
| Low dose
|
High dose
|
|||||
| Broth | SEVs | Broth | SEVs | Broth | SEVs | |
| Quinupristin | ||||||
| Peak (μg/ml or g) | 2.3 ± 0.6 | 1.6 ± 0.1 | 0.6 ± 0.1 | UD | 3.3 ± 0.5 | 4.6 ± 0.6 |
| Trough (μg/ml or g) | UDa | UD | NDb | ND | ND | ND |
| Half-life (h) | 0.9 ± 0.1 | 3.6 ± 0.5 | ND | ND | ND | ND |
| Kelim (h−1) | 0.8 ± 0.1 | 0.2 ± 0.0 | ND | ND | ND | ND |
| AUC24h (μg/ml/h) | 11.9 ± 1.5 | 28.6 ± 1.5 | 13.2 ± 1.0 | ND | 79.1 ± 12.9 | 108.2 ± 8.2 |
| Dalfopristin | ||||||
| Peak (μg/ml or g) | 5.3 ± 0.8 | 3.5 ± 0.2 | 0.9 ± 0.1 | UD | 5.9 ± 1.2 | 10.4 ± 1.4 |
| Trough (μg/ml or g) | UD | UD | ND | ND | ND | ND |
| Half-life (h) | 0.4 ± 0.0 | 1.1 ± 0.1 | ND | ND | ND | ND |
| Kelim (h−1) | 1.6 ± 0.1 | 0.7 ± 0.1 | ND | ND | ND | ND |
| AUC24h (μg/ml/h) | 20.3 ± 2.1 | 25.1 ± 1.8 | 20.4 ± 2.2 | ND | 121 ± 43.9 | 248.8 ± 6.3 |
a
UD, undetectable.
b
ND, not done.